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Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression  S.L. Bevill, P.L. Briant, M.E. Levenston,

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Presentation on theme: "Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression  S.L. Bevill, P.L. Briant, M.E. Levenston,"— Presentation transcript:

1 Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression  S.L. Bevill, P.L. Briant, M.E. Levenston, T.P. Andriacchi  Osteoarthritis and Cartilage  Volume 17, Issue 8, Pages (August 2009) DOI: /j.joca Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Tibial plateau cartilage explant removal sites relative to medial and lateral menisci (gray). Central region explants are removed from regions of cartilage at meniscal margin (not covered by meniscus) and peripheral region explants removed from cartilage fully covered by meniscus. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Schematic illustrating two of four chambers of the pneumatic explant compression device. Four inline chambers allowed simultaneous loading of up to four cartilage explants in unconfined compression. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 (a) Calibration curve for pneumatic explant compression device and (b) sample waveform applied to cartilage explant. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

5 Fig. 4 Baseline expression levels for (a) CII and AGGR, (b) MMP-1, MMP-3, MMP-13, and ADAM-TS5, and (c) TIMP-1 and TIMP-2 in central and peripheral region cartilage explants (*P<0.05). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

6 Fig. 5 Relative expression levels for (a) CII and AGGR, (b) MMP-1, MMP-3, MMP-13, and ADAM-TS5, and (c) TIMP-1 and TIMP-2 in central and peripheral region cartilage explants. White bars indicate central region, gray bars indicate peripheral region and hatched fill indicates in vitro dynamic compression. * indicates significant difference in dynamic compression and FSC mRNA level within a region (P<0.05), † indicates significant difference between central and peripheral region response to dynamic compression (P<0.05). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

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