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Fig. 2 Cortical actomyosin regulates cell decision-making in response to hydraulic resistance. Cortical actomyosin regulates cell decision-making in response.

Published byIsabel Hidalgo Modified over 5 years ago

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Presentation on theme: "Fig. 2 Cortical actomyosin regulates cell decision-making in response to hydraulic resistance. Cortical actomyosin regulates cell decision-making in response."— Presentation transcript:

1 Fig. 2 Cortical actomyosin regulates cell decision-making in response to hydraulic resistance.
Cortical actomyosin regulates cell decision-making in response to hydraulic resistance. (A) Distribution pattern of MDA-MB-231 cells in branch channels of different hydraulic resistances in response to different pharmacological [(CK666 and Latrunculin A (LatA)] or molecular interventions (mDia1-KD) (n > 70 cells from three independent experiments for CK666 and mDia1-KD experiments and n > 20 cells from three independent experiments for LatA experiments). Data represent the mean with 95% confidence interval. P < 0.01 for the distribution of LatA-treated cells versus controls as indicated by χ2 test. (B) Decision-making times of MDA-MB-231 cells in response to different pharmacological (CK666 and LatA) or molecular interventions (mDia1-KD) (n > 30 cells from three independent experiments for each condition). Data represent the means ± SD. Mann-Whitney U test was performed, ****P < relative to scramble control (SC). Kruskal-Wallis with post hoc Dunn was performed, ****P < relative to vehicle control (VC). (C) Distribution pattern of MDA-MB-231 cells in branch channels of different hydraulic resistances in response to different pharmacological (blebbistatin) or molecular interventions (myosin-IIA or myosin-IIB KD) (n > 70 cells from three independent experiments for each condition). Data represent the mean with 95% confidence interval. P < 0.01 and P < for the distribution of blebbistatin-treated and myosin-IIA–KD cells, respectively, relative to controls as indicated by χ2 test. (D) Decision-making times of MDA-MB-231 cells in response to different pharmacological (blebbistatin) or molecular interventions (myosin-IIA or myosin-IIB KD) (n > 40 cells from three independent experiments for each condition). Data represent the means ± SD. Kruskal-Wallis with post hoc Dunn was performed, *P < 0.05 relative to scramble control. Mann-Whitney U test was performed, ****P < relative to vehicle control. Runchen Zhao et al. Sci Adv 2019;5:eaaw7243 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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