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The Molecular Harbingers of Early Mammalian Embryo Patterning

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Presentation on theme: "The Molecular Harbingers of Early Mammalian Embryo Patterning"— Presentation transcript:

1 The Molecular Harbingers of Early Mammalian Embryo Patterning
Jun Wu, Juan Carlos Izpisua Belmonte  Cell  Volume 165, Issue 1, Pages (March 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Molecular Heterogeneity Underlies Biased Lineage Segregation in 4-Cell Mouse Embryo Heterogeneous gene expression and transcription factor-DNA binding dynamics pre-pattern the 4-cell mouse embryo for biased fate contribution to either inner cell mass (ICM) or trophectoderm (TE) in the blastocyst. Sox21 is among the most highly heterogeneous genes at the 4-cell stage. Sox21 expression is likely controlled by dynamic SOX2-DNA binding, which is also different among 4-cell blastomeres. Sox21 suppresses Cdx2 expression and TE fate and predisposes blastomeres toward ICM. P(ICM), probability of ICM fate; P(TE), probability of TE fate. Cell  , 13-15DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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