1. Efficacy of BP2 in treatment of biomaterial-associated S
Efficacy of BP2 in treatment of biomaterial-associated S. epidermidis infection.
Efficacy of BP2 in treatment of biomaterial-associated S. epidermidis infection. One hour after implantation of biomaterials and challenge with 106 CFU of S. epidermidis RP62a, mice received an injection of 50 μl saline or BP2 (5 mg/kg) subcutaneously along each implant. Mice were sacrificed after 24 h, and numbers of CFU adherent to the implants and present in peri-implant tissue were assessed. Two-sample comparisons were made using a two-tailed Mann-Whitney rank sum test. The significance of differences between the frequencies of categorical variables was determined using Fisher's exact test.
Paulus H. S. Kwakman et al. Antimicrob. Agents Chemother. 2006; doi: /AAC