1. Schematic representation of intracellular inflammatory pathway illustrating that both hyperoxia and mechanical lung injury from excessive stretch or shearing use the same intracellular pathways for initiating the inflammatory cascade.
Schematic representation of intracellular inflammatory pathway illustrating that both hyperoxia and mechanical lung injury from excessive stretch or shearing use the same intracellular pathways for initiating the inflammatory cascade. NF-κB = nuclear transcription factor kappa B; PAI-1 = plasminogen activator inhibitor-1; mRNA = messenger ribonucleic acid. See text for a detailed description.
Richard H Kallet, and Richard D Branson Respir Care 2016;61:
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