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HIT/HITT and alternative anticoagulation: current concepts

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Presentation on theme: "HIT/HITT and alternative anticoagulation: current concepts"— Presentation transcript:

1 HIT/HITT and alternative anticoagulation: current concepts
E Pravinkumar, N.R. Webster  British Journal of Anaesthesia  Volume 90, Issue 5, Pages (May 2003) DOI: /bja/aeg063 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Mechanism of action of heparin–PF4–IgG complex and the vicious circle that leads to thrombus formation and platelet destruction. IgG=immunoglobulin G; PF4=platelet factor 4; GP=glycoprotein. British Journal of Anaesthesia  , DOI: ( /bja/aeg063) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Actions of thrombin. NO=nitric oxide; PgI2=prostaglandin I2; t-PA=tissue plasminogen activator. Adapted with permission from Fuster and Verstraete.22 British Journal of Anaesthesia  , DOI: ( /bja/aeg063) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions


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