1. Stability of Adhesion Clusters and Cell Reorientation under Lateral Cyclic Tension 
Dong Kong, Baohua Ji, Lanhong Dai 
Biophysical Journal 
Volume 95, Issue 8, Pages (October 2008)
DOI: /biophysj
Copyright © 2008 The Biophysical Society Terms and Conditions

2. Figure 1
Schematic illustration of the side view (A) and top view (B) of the adhered cell under external strain. The dashed line in B denotes the adhered cell with a different orientation, characterized by angle θ. (C) Magnification of the adhesion cluster showing how the adhesion plaque (upper plate) couples the adhesion bonds and the stress fiber. The semimajor axis of the adhered cell is kept constant at l=10μm. (D) Illustration of the bond deformation under lateral force.
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions

3. Figure 2
Flow chart of the numerical scheme for calculations of the mean fraction of bound bonds of the adhesion cluster under cyclic lateral force.
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions

4. Figure 3
(A) Dependence of the mean fraction of bound bonds on the external strain, ε0, at a different reverse rate constant, koff0. In the calculation, we chose θ=0,ω=1,κ=0.22,γ=2.5, and kon0=100. (B) Evolution of the fraction of bound bonds as a function of time at ε0=0.03, with koff0=1,2,5, and 10 (top to bottom). The larger the koff0, the larger is the fluctuation of the fraction of bound bonds.
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions

5. Figure 4
(A) Dependence of the mean fraction of bound bonds on the external strain, ε0, at different frequency, ω. (B) Extension of the stress fiber as a function of time. In the calculation, we chose θ=0,κ=0.22,γ=2.5,koff0=1, and kon0=100.
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions

6. Figure 5
(A) Effect of the stiffness of the stress fiber on the stability of the adhesion cluster. In the calculation, we chose θ=0,γ=2.5,koff0=1, and kon0=100. (B) Extension of the stress fiber as a function of time at ε0=0.05.
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions

7. Figure 6
Effect of the relaxation time of the stress fiber on the stability of the adhesion cluster. In the calculation, we chose θ=0,γ=2.5,koff0=1, and kon0=100.
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions

8. Figure 7
Dependence of the mean fraction of bound bonds on the external strain, ε0, at different angle θ. In the calculation, we chose ω=1,κ=0.22,γ=2.5,koff0=2, and kon0=100. (A) v=0.5. (B) v=0. Insets show the stretching modes, i.e., simple elongation and pure uniaxial stretching, respectively.
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions

9. Figure 8
Force scale diagram for the growth and disassembly of focal adhesions. The growth zone denotes the force range for FA growth, Fa<F<Fb, described by Nicolas et al. (23), and the disassembly zone corresponds to F>Fc (the force range Fb<F<Fc corresponds to the stable zone) in the model described here. In the growth zone, the force-induced growth of FA originates from the addition of a new integrin molecule and its associated intracellular proteins to the FA through an “integrinC-integrinC” interaction (“intracelluar” interaction). However, in the disassembly zone, disassembly of the FA is caused by disassociation of the adhesion molecules on cells (integrin receptors) from their ligands on the ECM (“cell-ECM” interaction).
Biophysical Journal  , DOI: ( /biophysj )
Copyright © 2008 The Biophysical Society Terms and Conditions