1. Formation of the ventral telencephalic corridor in the Pdn mutant VT
Formation of the ventral telencephalic corridor in the Pdn mutant VT. A–H, Coronal sections through the VT of control (A–D) and Pdn mutant embryos (E–H) hybridized with the indicated probes.
Formation of the ventral telencephalic corridor in the Pdn mutant VT. A–H, Coronal sections through the VT of control (A–D) and Pdn mutant embryos (E–H) hybridized with the indicated probes. A, E, Ebf1 expression marks future corridor cells from their site of origin in the LGE in E11.5 control and Pdn mutant embryos. B, F, In E13.5 control embryos, Ebf1-expressing cells settle dorsal and ventral to the globus pallidus corresponding to the internal (ic) and external (ec) capsule, respectively. In Pdn mutants, the external capsule does not form properly. C, G, Isl1/2 immunohistochemistry revealing the distribution of corridor cells. Isl1/2+ cells are more dispersed in the MGE mantle of Pdn/Pdn embryos. D, H, Nkx2.1 in situ hybridization labels MGE progenitor cells and the globus pallidum (gp), which has an abnormal size in Pdn mutants. ctx, Cortex.
Dario Magnani et al. J. Neurosci. 2010;30:
©2010 by Society for Neuroscience