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Published byAshlynn Horton Modified over 5 years ago
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Devouring the Hematopoietic Stem Cell: Setting the Table for Marrow Cell Transplantation
Morton J Cowan, Hans-Peter Kiem Molecular Therapy Volume 24, Issue 11, Pages (November 2016) DOI: /mt Copyright © 2016 American Society of Gene & Cell Therapy Terms and Conditions
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Figure 1 “Setting the table” for engraftment of donor hematopoietic stem cells (HSCs). (a) Antibody-dependent cell-mediated phagocytosis–mediated “devouring” of HSCs with anti-CD47 blocking a “don't eat me” signal. (b) Antibody-mediated killing of HSCs by saporin (SAP) via blocking of protein synthesis. SIRPα, signal regulatory protein α. Molecular Therapy , DOI: ( /mt ) Copyright © 2016 American Society of Gene & Cell Therapy Terms and Conditions
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