1. Integrated mRNA and microRNA expression and DNA methylation clusters.
Integrated mRNA and microRNA expression and DNA methylation clusters. A, clustered heatmap of highly variable mRNAs and microRNAs. Sample identifier sequences are shown at the bottom. B, plots showing total number of mutations (top) and average ploidy (bottom) per sample for expression clusters 1 and 2. Median or mean values are shown by bars. P values are indicated in the top left and calculated by Mann–Whitney test or Student t test. C, clustered heatmap of bimodally methylated probes. Methylated probes are shown in red. D, plot showing the total number of CNAs per sample for methylation clusters 1 and 2.
Curtis R. Pickering et al. Cancer Discovery 2013;3:
©2013 by American Association for Cancer Research