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Janet Powell, MD, Roger M. Greenhalgh, MD  Journal of Vascular Surgery 

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1 Cellular, enzymatic, and genetic factors in the pathogenesis of abdominal aortic aneurysms 
Janet Powell, MD, Roger M. Greenhalgh, MD  Journal of Vascular Surgery  Volume 9, Issue 2, Pages (February 1989) DOI: / (89) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Elastin content and elastase activity in aortic media. Symbols are used to differentiate aortic media from aneurysms (■), stenosed atherosclerotic aorta (•), and normal aorta (▴). Journal of Vascular Surgery 1989 9, DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 DNA content of smooth muscle cells from aortic explant cultures. Replicate explant cultures (n = 8) were set up in 30 mm dishes. The cells were fixed with ice-cold 5% trichloracetic acid at intervals of 4 days and the DNA content quantitated fluorometrically. Each point shows results from at least four separate biopsies and data are shown as mean ± standard error. Smooth muscle cells from abdominal aorta (aneurysmal, stenotic, or normal) cease to proliferate after 12 to 16 days in culture; cells from thoracic aortic aneurysms continue to proliferate after 28 days in culture. Journal of Vascular Surgery 1989 9, DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Restriction fragment length polymorphisms of type III collagen genes in patients with abdominal aortic aneurysm and stenosing disease of the abdominal aorta. The two polymorphic bands at 2.1 and 1.6 Kb obtained by EcoRI digestion are shown. Patients in lanes 5, 6, 8, and 9 are women with abdominal aortic aneurysms. Patients in lanes 4, 7, and 10 have stenosing disease of the abdominal aorta and patients in lanes 1 through 3 are men with aortic aneurysms. Journal of Vascular Surgery 1989 9, DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Collagenase activity in aortic media from stable and ruptured aortic aneurysms. The total content of latent collagenase secreted into tissue culture medium is much greater in ruptured aortic aneurysms, but further stimulation by macrophage-conditioned medium is minimal (unshaded bar). Collagenase from stable aortic aneurysms can be stimulated sixfold by secretory products from cultured macrophages (unshaded bar). On the right, the same data are shown with respect to cellular content (DNA) rather than tissue wet weight. The difference between ruptured and unruptured aneurysms is much diminished, suggesting that cellular infiltration is responsible for the increased collagenase in ruptured aneurysmal tissue. All data are shown as mean ± standard deviation. Journal of Vascular Surgery 1989 9, DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

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