1. Tlr4−/− attenuates symptomatic parameters of gut toxicity: diarrhea and weight loss.
Tlr4−/− attenuates symptomatic parameters of gut toxicity: diarrhea and weight loss. Diarrhea profiles shown for WT BALB/c mice (A) and BALB/c-Tlr4−/−billy mice (B) treated with 270 mg/kg of irinotecan, as well as vehicle-treated controls (C and D). Diarrhea data are expressed as a percentage of total animals (per time point) with a particular grade of diarrhea. Data were analyzed using a χ2 test. Diarrhea was most significant at 24 hours after treatment in both treatment groups. Diarrhea was significantly improved in BALB/c-Tlr4−/−billy mice compared with WT (***, P < ). E, weight loss over the 96-hour time course. Data displayed as a percentage of weight change from baseline (0 hours). A Kruskal–Wallis with post hoc testing was performed to identify statistical significance. BALB/c-Tlr4−/−billy mice had significantly less body weight loss at 24 hours (**, P = 0.003), 48, 72, and 96 hours (***, P < ).
Hannah R. Wardill et al. Mol Cancer Ther 2016;15:
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