Presentation is loading. Please wait.

Presentation is loading. Please wait.

Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma  Erik B. Hysinger, MD, Jeffrey D. Roizen,

Similar presentations


Presentation on theme: "Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma  Erik B. Hysinger, MD, Jeffrey D. Roizen,"— Presentation transcript:

1 Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma  Erik B. Hysinger, MD, Jeffrey D. Roizen, MD, PhD, Frank D. Mentch, PhD, Lyam Vazquez, MD, John J. Connolly, PhD, Jonathan P. Bradfield, BS, Berta Almoguera, PhD, Patrick M. Sleiman, PhD, Julian L. Allen, MD, Michael A. Levine, MD, Hakon Hakonarson, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 6, Pages e4 (December 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Multivariate logistic regression model stratified by race comparing the odd ratio (OR) of asthma cases. B, Multivariate logistic regression model stratified by race comparing the OR of severe asthma exacerbations. Multivariate Poisson regression with robust variance stratified by race comparing the incidence rate ratio (IRR) of severe asthma exacerbations for cases with at least 1 severe exacerbation. OR/IRR is for a 10-ng/mL change in serum 25(OH)D concentration. All models are adjusted for age, sex, body mass index Z score, and month. Error bars indicate the 95% CI. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Center for Applied Genomics study cohorts.
Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 Algorithm for the identification of asthma and asthma severity. LABA, Long-acting beta-agonist; LAMA, long-acting muscarinic antagonists; LTA, leukotriene antagonists. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions


Download ppt "Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma  Erik B. Hysinger, MD, Jeffrey D. Roizen,"

Similar presentations


Ads by Google