1. Lecture Order 1) Receptor Trafficking Scaffolding Proteins at the PSD
NS1 Spring 2010
Lecture Order
1) Receptor Trafficking
Scaffolding Proteins at the PSD
Signaling at the PSD

2. Trends Neurosci. 25:578, 2002

6. J. Neurosci. 19:6298, 1999

7. TINS 30:407, 2007

8. Control of NMDA surface expression through ER retention signal

9. Tubulin -> microtubules Microfilaments -> actin
<----Dynamic polymers
<----Stable, only in neurons
Neurofilaments -> NF-H, -M, -L
Nature Reviews Neurscience 10:319, 2009

10. Nature Reviews Neurscience 10:319, 2009

12. Nature Reveiws MolCelBio 10:682, 2009

13. Science 279:519, 1998

14. cargo

15. minus-end directed
motor
plus-end directed
motor

16. plus-end directed motor: axoneme travels toward stable tail (-)
Axoneme Assay
plus-end directed motor:
axoneme travels toward
stable tail (-)
minus-end directed motor:
axoneme travels toward
unstable head (+)
Science 288:1796, 2000
Nature 347:780, 1990

22. Microtubule Motility Assay
(plus directed motor)
YFP-KIF17

23. J. Neurosci. 23:131, 2003

24. Nature Neurosci. 3:415, 2000

25. Role of endocytosis of ion channels in regulating synaptic efficacy
Science 285:215, 1999

26. Nature Rev. Neurosci. 1:161, 2000

27. TINS 31:559, 2008

28. AMPA receptors and LTP/LTD

29. Nature Rev. Neurosci. 2:315, 315

30. Neuron 36:435, 2002