1. Introduction
Michael T. Parra MD
Medical Director, PAS

2. PROBLEM – National Concern
60 Million Americans suffer from allergies
40% of children – 30% of adults
90% of asthma is triggered by allergies
Allergies increased 50% since 1997
Testing is traumatic and treatment is time consuming

3. RESULT – Mask Symptoms Approximately 95% of patients go untreated!
Americans spent $17.5 Billion in 2010* ($18B in 2015)
antihistamines, decongestants, inhalers, steroids
pills, eye drops, nasal sprays
Still suffer dreaded trips to the ER
Asthma attacks during sporting events, etc.
* Schaffer F. National Impact of Allergies. Academy of Allergy and Asthma in Primary Care.  April )

4. PROBLEM – Why? (Standard Testing)
Scratch Tests
Painful – skin pricks
Limited - only allergens
Time consuming – minutes
30% false positive results
Subjective – Observation alone
Non-measurable as a repeatable test

5. PROBLEM – Why? (Standard Testing)
Intradermal Shots
Potential risks – insert food & other allergens
Subjective – Observation only
Non-measurable

6. PROBLEM – Why? (Standard Testing)
Food Challenge
Potential risks – insert concentrated amount of food
Tragic Result
Alastair Watson – Children’s Hospital of AL – 07/30/17

7. PROBLEM – Why? (Standard Treatment)
Weekly shots (SCIT)
Time consuming
(missed school & work)
Children are afraid of shots
Titrate up 6-9 months to reach the maintenance level
Do not feel better for at least 9 months, 84% drop out rate

8. PROBLEM – Why? (Standard Treatment)
Sublingual drops (SLIT)
Hold under tongue for two minutes – forget to do
Unpleasant taste
Compliance 60%

9. NO NEW DEVELOPMENTS IN ALLERGY TESTING AND TREATMENT PROTOCOLS IN USA FOR 20 YEARS …UNTIL NOW!

10. SOLUTION – NEW IN-OFFICE TEST & TREATMENT PROGRAM
Now you can test and treat your allergy patients in your office!
No longer need to refer over 95% of allergy patients to allergists
As simple as 1…2…3

11. STEP ONE – NEW TEST Finger-prick blood test – 120 allergens
(compared to with scratch tests)
Unique Next-Generation Microarray Chip Assay Most advanced – FDA cleared technology
Simply drop 4 drops on specialized paper
Airborne, environment & food
50 Allergen non-inhalant panel
Foods, insects, latex, penicillin
70 Allergen environmental inhalant panel
Animals, fungi, grass, insects, molds, trees, weeds

12. FINGER-PRICK BLOOD TEST
Sensitivity and Specificity Results
Allergy tests correctly scored 20 positive and negative serum specimens for a total of 1,160 analytes for 100% sensitivity and 100% specificity for the inhalant allergens.
Allergy tests correctly scored 20 positive and negative serum specimens for a total of 660 analytes for 100% sensitivity and 100% specificity for the non-inhalant allergens.

13. FINGER-PRICK BLOOD TEST
Studies – Asthma & Food
Study of 215 children (1-14yrs) using ImmunoCAP Rapid testing demonstrated effective ( %) correct identification of allergic sensitization in children with recurrent asthma.
Prospective food allergy study of this technology demonstrating the importance of quantitative IgE measurements in 100 children, referred for food allergy evaluation tested for IgE to egg, milk, peanut, soy, wheat, and fish after dx of food allergy established on hx and food challenge. Results showed greater than 95% of food allergies were correctly identified, and could predict clinical reactivity (positive food challenges) with greater than 95% certainty.
Diaz-Vazquez C, et al. Accuracy of ImmunoCAP(R) rapid in the diagnosis of allergic sensitization in children between 1 and 14 years with recurrent wheezing: the IReNE study. Pediatric Allergy Immunol 2009;20:601-9.
Sampson HA. Utility of food specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001;107:891-6.

14. STEP ONE – NEW TEST Finger-Prick Blood Test Safe, Fast & Easy
Four Drops of Blood
Measurable results
Comprehensive
120 Allergens vs with Scratch Test
Eliminates need for Food Challenge – Safe!

15. Non-Inhalant and Environmental Allergens
Acremonium, Alder, Alfalfa Pollen, Alternaria, Aspergillus, Auareobasidum, Australian Pine, Bahia grass, Bald cypress, Bayberry (wax myrtle), Bermuda grass, Birch White, Box Elder, California Live Oak, Candida Albicans, Cat Hair, Cattle Hair, Cedar Red, Cedar Mountain, Cladosporium, Cocklebur, Cockroach Mix, Cottonwood, Curvularia, Dog Hair, Drechslera, Elm American, Elm Chinese, English planain, Epicoccum, Fusarium, Horse Hair, Johnson Grass, June Grass, Juniper, Kochia, Lamb's Quarters, Maple Pollen, Mite Farinae, Mite Pteronyssinus, Mouse Hair, Mucor Plumbeus, Mugwort, Olive Russian, Pecan Pollen, Perennial Ryegrass, Phoma Herbarum, Queen Palm, Rough Pigweed, Russian Thistle, Pine White, Poplar White, Privet, Queen Palm, Ragweed False, Ragweed Western, Red Birch, Red Mulberry, Red Oak, Rough Marsh Elder, Sagebrush, Shagbark Hickory, Sheep Sorrel, Short Ragweed, Sycamore American, Tall Ragweed, Timothy Grass, Virginia Live Oak, Walnut Black Pollen, White Ash, White Oak, Willow Black

16. Food Allergens
Almond, Apple, Banana, Barley, Beef, Brazil Nut, Buckwheat, Casein, Carrot, Celery, Chicken, Clam, Cod Fish, Corn, Crab, Egg White, Egg Yolk, Flounder, Garlic, Green Pea, Halibut, Lobster, Milk, Mustard Seed, Oat, Oyster, Peach, Peanut, Pork, Rye, Salmon, Sesame Seed, Shrimp, Soybean, Strawberry, Tomato, Tuna, Walnut, Wheat, Yeast

17. STEP TWO – PRESCRIBE Write prescription for customized serum
Compounding pharmacy
Mixes unique allergen serum, based
on finger stick non-food allergen results

18. STEP THREE – TOOTHPASTE
Oral Mucosal Immunotherapy (OMIT)
Serum is mixed in OMIT base to create prescribed toothpaste
Patient returns quarterly for checkup and receive next 90-day supply

19. STEP THREE – NEW TOOTHPASTE
Safe - Natural
More effective than SCIT (shots) or SLIT (sublingual drops)
Begin at maintenance level (vs. titrate up 6-9 months)
Patients feel better – faster
Increase compliance

20. BENEFITS – To Practice Solve a national concern New revenue:
Provide testing & treatment in office
Measurable Results
Natural, safe, effective regimen specifically designed for non-food allergies
New revenue:
Quarterly office visits
Admin fee with Treatment

21. BENEFITS – To Patient Not Scary/Quick - Prick finger
Safe – Drop blood on card for testing
Effective – Natural therapy
Simple – Brush teeth for 2 min
Tastes good
Berry or Mint flavor

22. BENEFITS – To Parents/Patients
Save Time
No weekly trips to allergist
No missed work or school
Save Money
Gas, parking fees, time
No copays ($20-$50 per visit)
Easy & sustainable treatment
Brush teeth daily for 2 minutes

23. SUMMARY Unique Microarray Chip Assay (Test) Prescribe Toothpaste
Drop 4 Drops of blood on card (safe/quick)
120 Allergens (vs with scratch testing)
Measurable results (from test to test)
Prescribe
Unique serum per patient
Toothpaste
Most effective delivery system (start at maintenance level vs. titrating up 6-9 months like with shots)
Saves money ($120 for shots vs. $105)

24. RESULT Replace or enhance out-dated:
Scratch test
Intradermal test
Food Challenge
Replace weekly shots (time consuming)
Replace sublingual drops (unpleasant taste)
Treat 95% of patients in office! (currently untreated)
Feel better – sooner
Compliant – completion of regimen

25. LEARN MORE… www.PediatricAllergySolutions.com Is this safe?
Does it work?
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