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Effects of pulmonary capillary wedge pressure (Ppcw) and stroke volume (SV) on systolic (s), diastolic (d) and mean (m) pulmonary arterial pressures (Ppa). Effects of pulmonary capillary wedge pressure (Ppcw) and stroke volume (SV) on systolic (s), diastolic (d) and mean (m) pulmonary arterial pressures (Ppa). If Ppcw is directly transmitted to diastolic Ppa, there is a disproportional increase in systolic Ppa and mean Ppa depending on SV. The transpulmonary pressure gradient (TPG) increases, but the diastolic Ppa/Ppcw gradient (DPG) is independent of both Ppcw and SV. The equations from [14] were used to model the response of the vasculature. Robert Naeije et al. Eur Respir J 2013;41: ©2013 by European Respiratory Society
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