1. Comparative Studies of Biologics in Ulcerative Colitis

3. This program will include a discussion of data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

4. Introduction

5. Patient Case Michael, 34-Year-Old Man

6. Therapy Selection Considerations

7. Types of Comparative Analyses

8. Indirect Evidence: Meta-Analyses

9. New Generation of Meta-Analyses Network Meta-Analyses

10. Meta-Analyses Advantages and Disadvantages

11. Real-World Evidence (RWE)

12. VICTORY Consortium Real-World Cohort

13. Real-World Evidence Advantages and Disadvantages

14. Head-to-Head Studies in IBD

15. Types of Head-to-Head Trials

16. Head-to-Head Trials Advantages and Disadvantages

17. VARSITY Study Design

18. VARSITY Results

19. VARSITY Response Over Time

20. VARSITY Histology Indexes

21. Importance of Histology as Therapeutic Goal in UC

22. What Should Be the Target in UC? Expert Perspective

23. Data That Will Be Useful From VARSITY Faculty Perspective

24. VARSITY Steroid-Free Remission

25. Head-to-Head Trials in the Pipeline in UC

27. VARSITY Trial -- How Will the Results Influence Your Practice
VARSITY Trial -- How Will the Results Influence Your Practice? -- Expert Perspective

28. Concluding Remarks

29. Abbreviations

30. Abbreviations (cont)