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Fig. 2 Suv420h dKO mice have improved metabolic parameters.

Published byLívia Quintanilha Modified over 5 years ago

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Presentation on theme: "Fig. 2 Suv420h dKO mice have improved metabolic parameters."— Presentation transcript:

1 Fig. 2 Suv420h dKO mice have improved metabolic parameters.
Suv420h dKO mice have improved metabolic parameters. (A) Basal glycemia measured in overnight-fasted control and dKO mice (n = 6 per genotype). Glucose levels were measured from the tail vein using a standard glucometer. (B) GTT performed in control and dKO mice after overnight fasting. The test was performed by intraperitoneally injecting d-glucose (2 g/kg). Blood glucose levels were measured at the indicated time points (5, 10, 15, 30, 45, 60, and 120 min after glucose administration) from the tail vein using a standard glucometer (n = 6 per genotype). a.u., arbitrary units. (C and D) Gene expression analysis of Suv420h1, Suv420h2, Ucp1, Pgc1a, and Dio2 mRNA by RT-qPCR performed in iBAT of mice with or without cold exposure (n = 6 per genotype). (E and F) Left: Basal core rectal temperature of control and dKO mice recorded at room temperature (RT) using a rectal probe (RET-3, ThermoWorks). Right: Rectal temperature in acute cold challenge (right) (n = 6 per genotype) measured hourly for 6 hours. Values are expressed as mean ± SEM; t test; *P < 0.05; **P < 0.01; ***P < n.s., not significant. Simona Pedrotti et al. Sci Adv 2019;5:eaav1472 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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