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Pressure-diameter relationship in the human greater saphenous vein

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1 Pressure-diameter relationship in the human greater saphenous vein
Wim Stooker, PhD, Murat Gök, Pieter Sipkema, PhD, Hans W.M Niessen, PhD, Alexi Baidoshvili, MD, Nico Westerhof, PhD, Evert K Jansen, MD, Charles R.H Wildevuur, PhD, Léon Eijsman, PhD  The Annals of Thoracic Surgery  Volume 76, Issue 5, Pages (November 2003) DOI: /S (03)

2 Fig 1 Smooth muscle cell/extracellular matrix score, which relates to vascular elastic properties, demonstrates no significant difference in SMA/ECM score of circular and longitudinal (longit.) smooth muscle layers between upper and lower leg saphenous vein grafts. Data are expressed as mean ± standard error of mean. (SMA = smooth muscle cell actin antibody; ECM = extracellular matrix.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3 Fig 2 Representative pressure strain curve. Pressure-diameter relation. ▿ = lower leg; □ = upper leg. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4 Fig 3 Pressure-normalized diameter relationship. Curves are generated with nonlinear regression (see Methods). Two way ANOVA with Bonferroni test illustrates the difference in relative response between unsupported upper and lower leg saphenous vein grafts to be significant at pressures 75 (p < 0.05), 100, 125, and 150 cm H2O (p < 0.001). The difference between upper leg saphenous vein, with and without fibrin glue support, and lower leg, with and without fibrin glue support, is significant from 30 (p < 0.01), and from 40 to 150 cm H2O (p < 0.001). The difference between upper and lower leg saphenous vein with fibrin glue support is significant at 125 (p < 0.01) and 150 cm H2O (p < 0.001). (YMAX = ΔD/Dmax; N = Hill coefficient; ▿ = lower leg; □ = upper leg; ■ = upper leg with fibrin glue; ▾ = lower leg with fibrin glue.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5 Fig 4 Distensibility coefficient. Two way ANOVA with Bonferroni posthoc test illustrates the difference in distensibility between the unsupported upper and lower leg saphenous vein grafts to be significant only at 50 cm H2O (p < 0.05). The difference in distensibility in the supported upper and lower leg vein grafts is not significant. The difference in distensibility between supported and unsupported lower leg saphenous vein is significant in the pressure range of 30 to 75 cm H2O (p < 0.001). The difference in the higher-pressure range does not reach significance. The difference in distensibility between supported and unsupported upper leg saphenous vein grafts is significant in the 20 to 50 cm H2O range (p < 0.001), but is also significant in the high-pressure range of 100 to 150 cm H2O (p < 0.01). (▿ = lower leg, no fibrin glue; □ = upper leg, no fibrin glue; ■ = upper leg with fibrin glue; ▾ = lower leg with fibrin glue.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )


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