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Plasma concentration and urinary excretion of N-terminal proatrial natriuretic peptides in patients with kidney diseases  Martina Franz, Wolfgang Woloszczuk,

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Presentation on theme: "Plasma concentration and urinary excretion of N-terminal proatrial natriuretic peptides in patients with kidney diseases  Martina Franz, Wolfgang Woloszczuk,"— Presentation transcript:

1 Plasma concentration and urinary excretion of N-terminal proatrial natriuretic peptides in patients with kidney diseases  Martina Franz, Wolfgang Woloszczuk, Walter H. Hörl  Kidney International  Volume 59, Issue 5, Pages (May 2001) DOI: /j x Copyright © 2001 International Society of Nephrology Terms and Conditions

2 Figure 1 Plasma concentration (A) and urinary excretion (B) of two different N-terminal fragments of the proatrial natriuretic peptide [proANP(1-30) and proANP(31-67)] in patients with renal disease but preserved renal function and without proteinuria (▪) as compared with healthy controls (□). The fragments were determined by radioimmunoassay as described in the Methods section. Data are mean ± SD (N = 19); **P < compared with healthy controls (N = 16). Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

3 Figure 2 Plasma concentration (A) and urinary excretion (B) of two different N-terminal fragments of the proatrial natriuretic peptide [proANP(1-30) and proANP(31-67)] in patients with renal disease and normal serum creatinine (▪, N = 43), serum creatinine between 1.3 and 2.5 mg/dL (, N = 29), serum creatinine between 2.5 and 5.0 mg/dL (□, N = 39), and of those patients with a serum creatinine> 5.0 mg/dL (, N = 10). Data are mean ± SD; *P < and **P < compared with patients with normal serum creatinine. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

4 Figure 3 Plasma concentration (A) and urinary excretion (B) of two different N-terminal fragments of the proatrial natriuretic peptide [proANP(1-30) and proANP(31-67)] in patients with renal disease and urinary protein loss <0.15 g/24 h (▪, N = 23), urinary protein loss between 0.15 and 1.0 g/24 h (, N = 41), urinary protein loss between 1.0 and 3.0 g/24 h (□, N = 31), and of those patients with a urinary protein loss openface> 3.0 g/24 h (, N = 26). Data are mean ± SD; *P < 0.05 compared with patients with urinary protein loss <0.15 g/24 h. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

5 Figure 4 Plasma concentration (A) and urinary excretion (B) of two different N-terminal fragments of the proatrial natriuretic peptide [proANP(1-30) and proANP(31-67)] in patients with renal disease and normal serum creatinine. Comparison between nonproteinuric (□, N = 19) and proteinuric patients (▪, N = 17). Data are mean ± SD; P = NS. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions


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