1. Various impediments in the uptake and retention of radiolabeled antibodies in solid tumors and strategies to modulate these biological barriers.
Various impediments in the uptake and retention of radiolabeled antibodies in solid tumors and strategies to modulate these biological barriers. Following i.v. administration, radiolabeled antibodies reach tumor vasculature (1) and extravasate through the vascular endothelium (2) followed by diffusion through tumor interstitium (3 and 4). The radiolabeled antibodies recognize their target antigen on the surface of the tumor cells (5) and may remain surface bound or may be internalized (6). Adjacent boxes, various strategies that can improve the antibody uptake and/or retention at each of these steps; blue, examples of the modulators used.
Maneesh Jain et al. Clin Cancer Res 2007;13:
©2007 by American Association for Cancer Research