1. Apoptosis: Opening PANdora's BoX
Christoph Peter, Sebastian Wesselborg, Kirsten Lauber 
Current Biology 
Volume 20, Issue 21, Pages R940-R942 (November 2010)
DOI: /j.cub
Copyright © 2010 Elsevier Ltd Terms and Conditions

2. Figure 1
Cleavage and opening of pannexin 1 (Panx1) contributes to nucleotide release during apoptosis.
Panx1 has four transmembrane domains, intracellular amino (N) and carboxyl (C) termini, and two extracellular loops. The putative caspase-3/7 (Casp-3/7) cleavage site is depicted by the scissors. Upon caspase-mediated cleavage Panx1 channels open and contribute to nucleotide release, dye uptake and voltage-gated currents during apoptosis.
Current Biology  , R940-R942DOI: ( /j.cub )
Copyright © 2010 Elsevier Ltd Terms and Conditions