1. Normalizing the tumor microenvironment
Normalizing the tumor microenvironment Excess angiogenic molecules produced by cancer or stromal cells cause abnormal tumor vasculature. ECM-normalizing drugs can decompress the blood vessels, and anti-angiogenesis therapies can reverse many of the TME abnormalities, resulting in improved perfusion and immune cell infiltration and creation of an immunostimulatory microenvironment.
Lance L. Munn, and Rakesh K. Jain Science 2019;365:
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