1. (Top) Observed (symbols) and model-predicted (lines) response-time data for latanoprost at the 0.1, 1.0, and 10 µg dose levels in the cat eye.
(Top) Observed (symbols) and model-predicted (lines) response-time data for latanoprost at the 0.1, 1.0, and 10 µg dose levels in the cat eye. (Bottom) Simulated corresponding biophase time courses using final parameter estimates from the regression of the pharmacodynamic model to response-time data in the top panel. The thick dashed red line schematically shows the time course of test compound after intravenous and topical (tmax 10 minutes) dosing onto the cornea, with a plasma half-life of <10 minutes in rabbits and cynomolgus monkeys (Sjöquist et al., 1999).
Johan Gabrielsson et al. Pharmacol Rev 2019;71:89-122
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