1. Change in intercalated cell morphology in response to chronic acid-base status changes.
Change in intercalated cell morphology in response to chronic acid-base status changes. This transmission electron micrograph shows the apical membrane of type A cells from the collecting duct from a normal rat (A) and from a rat with acute respiratory acidosis (B). In the control animal prominent studs (arrowheads) are observed on tubulovesicular structures in the control rat (A), while they are more abundant on the apical membrane in the experimental animal (B). In another study, Brown and colleagues showed that these studs are H+-ATPase, both at the membrane and in the tubulovesicular subapical structures (57). The increase in the number of H+-ATPases (studs) at the apical membrane in the animal with acidosis (B) is coupled to an increase in membrane microprojections and a decrease in the number of tubulovesicular structures in the acidotic rat (B). (Original magnification: A, ×48,000; B, ×42,400.) Reproduced with permission from reference 10.
Ankita Roy et al. CJASN 2015;10:
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