Presentation is loading. Please wait.

Presentation is loading. Please wait.

CAT-02-106 displays very high in vivo stability as exemplified by a rat PK study. CAT-02-106 displays very high in vivo stability as exemplified by a rat.

Published byDjaja Budiaman Modified over 5 years ago

Similar presentations

Presentation on theme: "CAT-02-106 displays very high in vivo stability as exemplified by a rat PK study. CAT-02-106 displays very high in vivo stability as exemplified by a rat."— Presentation transcript:

1 CAT-02-106 displays very high in vivo stability as exemplified by a rat PK study.
CAT displays very high in vivo stability as exemplified by a rat PK study. Sprague-Dawley rats (3/group) were given a single i.v. bolus dose of 3 mg/kg CAT Plasma samples were collected at the designated times and were analyzed (as shown in Supplementary Fig. S1) for total antibody, total conjugate, and total ADC concentrations. Penelope M. Drake et al. Mol Cancer Ther 2018;17: ©2018 by American Association for Cancer Research

Download ppt "CAT-02-106 displays very high in vivo stability as exemplified by a rat PK study. CAT-02-106 displays very high in vivo stability as exemplified by a rat."

Similar presentations

HMGA2 is a SUMOylation target.

HMGA2 is a SUMOylation target.
A, Effect of folate-FITC (500 nmol/kg, 5 days/week) and/or sunitinib (20 mg/kg daily) therapy on the growth of M109 tumors in Balb/c mice. A, Effect of.

A, Effect of folate-FITC (500 nmol/kg, 5 days/week) and/or sunitinib (20 mg/kg daily) therapy on the growth of M109 tumors in Balb/c mice. A, Effect of.
2D PAGE/Western blotting analysis for the identification of possible post-translation modification of Hsp27 from the spinal cord tissue of the SCI rat.

2D PAGE/Western blotting analysis for the identification of possible post-translation modification of Hsp27 from the spinal cord tissue of the SCI rat.
HPLC tracings of resveratrol (RV) and its major sulfate conjugates M4/M5 in the plasma from three subjects. HPLC tracings of resveratrol (RV) and its major.

HPLC tracings of resveratrol (RV) and its major sulfate conjugates M4/M5 in the plasma from three subjects. HPLC tracings of resveratrol (RV) and its major.
Pirh2 promotes p73 ubiquitination in vivo.

Pirh2 promotes p73 ubiquitination in vivo.
Inhibition of FGFR signaling and tumor growth in SNU-16 xenograft model by administration of E7090. Inhibition of FGFR signaling and tumor growth in SNU-16.

Inhibition of FGFR signaling and tumor growth in SNU-16 xenograft model by administration of E7090. Inhibition of FGFR signaling and tumor growth in SNU-16.
Treatment with BLU9931 leads to tumor regression in the FGF19-amplified Hep 3B liver cancer model. Treatment with BLU9931 leads to tumor regression in.

Treatment with BLU9931 leads to tumor regression in the FGF19-amplified Hep 3B liver cancer model. Treatment with BLU9931 leads to tumor regression in.
Colonopshere-enriched proteins display functional interactions.

Colonopshere-enriched proteins display functional interactions.
NM-3 induces p21 levels and down-regulation of Cdk2 activity.

NM-3 induces p21 levels and down-regulation of Cdk2 activity.
Dan-dan Tian1, 2 et al. Acta Pharmacol Sin 2015; 36: 627–643;

Dan-dan Tian1, 2 et al. Acta Pharmacol Sin 2015; 36: 627–643;
Fig. 4. The effect of single-dose rozanolixizumab on the concentration of IgG subtypes in healthy subjects. The effect of single-dose rozanolixizumab on.

Fig. 4. The effect of single-dose rozanolixizumab on the concentration of IgG subtypes in healthy subjects. The effect of single-dose rozanolixizumab on.
Fig. 4. Clearance of 12-mer-1 from a nonhuman primate model.

Fig. 4. Clearance of 12-mer-1 from a nonhuman primate model.
CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.
Activity of MAC-321 (i. v. and p. o

Activity of MAC-321 (i. v. and p. o
Dan-dan Tian1, 2 et al. Acta Pharmacol Sin 2015; 36: 627–643;

Dan-dan Tian1, 2 et al. Acta Pharmacol Sin 2015; 36: 627–643;
unbound concentration µM

unbound concentration µM
Figure 3 Effect of IVIg on endogenous relative concentration (in mAb equivalents) of JCV AbSix patients shown in this figure have had John Cunningham virus.

Figure 3 Effect of IVIg on endogenous relative concentration (in mAb equivalents) of JCV AbSix patients shown in this figure have had John Cunningham virus.
(A) Plasma renin activity in Wistar rats, SHRs, and DOCA-salt rats, n = 8 to 9/group; data are presented as mean ± S.E.M. Dose-response relationship on.

(A) Plasma renin activity in Wistar rats, SHRs, and DOCA-salt rats, n = 8 to 9/group; data are presented as mean ± S.E.M. Dose-response relationship on.
QSOX1 is highly expressed in tumor cell lines but is not expressed in adjacent normal cells. QSOX1 is highly expressed in tumor cell lines but is not expressed.

QSOX1 is highly expressed in tumor cell lines but is not expressed in adjacent normal cells. QSOX1 is highly expressed in tumor cell lines but is not expressed.
Mean ± SEM concentration of insulin in plasma and CSF and glucose in plasma 30 min after the intraperitoneal administration of DET or NPH insulin at different.

Mean ± SEM concentration of insulin in plasma and CSF and glucose in plasma 30 min after the intraperitoneal administration of DET or NPH insulin at different.

Similar presentations

Ads by Google