1. Family studies of bipolar disorder.
Family studies of bipolar disorder. The relative risk of narrowly defined bipolar disorder (equivalent to DSMIV bipolar I disorder) in first degree relatives of bipolar probands is shown as a function of the number of subjects included in the study. Relative risk is defined as the ratio of risk of bipolar disorder in first degree relatives of bipolar probands to the risk in first degree relatives of controls or, for studies that did not include controls, to an assumed general population baseline risk of 1% (see text for further details). Numbers refer to papers in reference list. All studies can be seen to give a relative risk of greater than one (dashed line) and therefore provide evidence of familial aggregation of bipolar disorder.
Nick Craddock, and Ian Jones J Med Genet 1999;36:
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