1. Volume 4, Issue 3, Pages 182-191 (September 2001)
Intratumoral Adenovirus-Mediated Suicide Gene Transfer for Hepatic Metastases from Colorectal Adenocarcinoma: Results of a Phase I Clinical Trial 
Max W. Sung, Hsu-Chong Yeh, Swan N. Thung, Myron E. Schwartz, John P. Mandeli, Shu-Hsia Chen, Savio L.C. Woo 
Molecular Therapy 
Volume 4, Issue 3, Pages (September 2001)
DOI: /mthe
Copyright © 2001 American Society for Gene Therapy Terms and Conditions

2. FIG. 1
Percutaneous vector injection procedure under ultrasonographic monitoring. Three spinal needles (25 gauge, 3.5 inches) were percutaneously placed in a metastatic tumor in the liver. Small volume aliquots of the vector were injected along the path of each needle at points 1 cm apart to maximize tumor exposure to the vector.
Molecular Therapy 2001 4, DOI: ( /mthe )
Copyright © 2001 American Society for Gene Therapy Terms and Conditions

3. FIG. 2
Ultrasonograph showing liver mass before and after vector injection (patient 2–3). (A) Sagittal scan before vector injection showing a hypoechoic mass (arrowheards) in the liver. (B) After injection of the vector at multiple sites within the tumor, multiple echogenic foci within the tumor are seen due to microbubbles produced at each injection site.
Molecular Therapy 2001 4, DOI: ( /mthe )
Copyright © 2001 American Society for Gene Therapy Terms and Conditions

4. FIG. 3
Hematoxylin and eosin stains of biopsy sections of metastatic tumor in the liver (patient 3–2). (A) Adenocarcinoma with glandular features and desmoplastic reaction (before vector injection). Magnification, ×200. (B) Tumor necrosis with residual viable tumor cells (arrowheads) 11 weeks following vector injection. Magnification, ×200.
Molecular Therapy 2001 4, DOI: ( /mthe )
Copyright © 2001 American Society for Gene Therapy Terms and Conditions