1. David J.A. Jenkins et al. JACC 2018;71:2570-2584
Forest Plot of Vitamin B Complex Supplementation and Stroke Risk The diamond represents the pooled risk estimate. Interstudy heterogeneity was tested using the Cochran Q statistic (chi-square) at a significance level of p < 0.10 and quantified by the I2 statistic. This 10% stroke reduction comes from trials that also include folic acid and from areas with folic acid fortification. These results also support not only B-complex supplementation but also the positive effect of folic acid in stroke prevention. The NNT for vitamin B complex supplementation and stroke risk is 250. *Data for folic acid, B6, and B12 versus placebo from Bønaa et al. (36). †Data for folic acid, B6, and B12 versus placebo from Ebbing et al. (38). Abbreviations as in Figures 2 and 4.
David J.A. Jenkins et al. JACC 2018;71:
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