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SiRNA silencing of CDH3, CLDN1, KRT23, and MMP7 (A–D) in adenoma and CRC cell lines significantly reduces cell proliferation. siRNA silencing of CDH3,

Published byMaría Josefa Araya Modified over 5 years ago

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Presentation on theme: "SiRNA silencing of CDH3, CLDN1, KRT23, and MMP7 (A–D) in adenoma and CRC cell lines significantly reduces cell proliferation. siRNA silencing of CDH3,"— Presentation transcript:

1 siRNA silencing of CDH3, CLDN1, KRT23, and MMP7 (A–D) in adenoma and CRC cell lines significantly reduces cell proliferation. siRNA silencing of CDH3, CLDN1, KRT23, and MMP7 (A–D) in adenoma and CRC cell lines significantly reduces cell proliferation. PCNA protein was quantitated in transfected CRC and adenoma cells. All assays are done in triplicate, cell lines are grouped by phenotype (MSI: HCT116, LoVo; CIN: SW48, RKO; CIMP: FET, SW480), and results are normalized to tubulin and PCNA expression in csiRNA. Error bars note SD, and calculated P-values are for differences in PCNA expression in csiRNA and each phenotype. csiRNA (control nontargeting siRNA), **P < Elizabeth K. Broussard et al. Cancer Prev Res 2013;6: ©2013 by American Association for Cancer Research

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