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M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia The opening of KATP channels and intact activity of M‐LDH.

Published byGwenda Collins Modified over 5 years ago

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Presentation on theme: "M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia The opening of KATP channels and intact activity of M‐LDH."— Presentation transcript:

1 M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia
The opening of KATP channels and intact activity of M‐LDH is required for Kir6.2/SUR2A/M‐LDH‐mediated resistance. Original frames and whole‐cell recordings under control and ischemic conditions with corresponding bar (intracellular Ca2+ levels, frames) and scatter‐line graphs (whole‐cell recordings) of A549 cells transfected with Kir6.2/SUR2A/M‐LDH in the presence of 10 μM glybenclamide (A) and transfected with Kir6.2/SUR2A plus 193gly‐M‐LDH (B) (single‐amino acid mutated form of M‐LDH with greatly reduced LDH activity; glybenclamide was absent). Scale bar, 20 μm. Vertical bars represent mean ± SEM; points represent mean (n = 5–9). *P <0.05. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO J, Volume: 21, Issue: 15, Pages: , First published: 01 August 2002, DOI: ( /emboj/cdf388)

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