1. Representative staining of bone marrow aspirates collected from a patient at baseline and after 1 cycle of treatment with 45 mg/m2 selinexor + 20 mg dexamethasone, twice weekly.
Representative staining of bone marrow aspirates collected from a patient at baseline and after 1 cycle of treatment with 45 mg/m2selinexor + 20 mg dexamethasone, twice weekly. The patient achieved a best response of PR while on study. Staining shows increased apoptosis (Apoptag) and nuclear accumulation of known TSP cargoes of XPO1 (p53, survivin, Rb, and Smad4).
Christine Chen et al. Blood 2018;131:
©2018 by American Society of Hematology