1. Week 2: Cable properties (passive membrane properties and disease)
BIOL3833
Week 2: Cable properties
(passive membrane properties and disease)

2. Agenda
Announcements
Brief lecture: “Passive properties and disease states” (15 min)
Work on simulation exercises (~60 min).

3. A quick review

4. Start with passive properties of a spherical cell – the simplest case we have.

6. 3D Purkinje cell reconstruction

7. Vrest = -60mV
Depolarize to -50 mV

10. Rm Cm Ra I

11. Rm Ra
How would you increase conduction velocity/efficiency by changing Ra?
- What are the limits on this strategy?

12. Rm Ra
How would you increase conduction velocity by changing Rm?

14. Rm Cm Ra I

16. On to simulation assignment
Today is competence based – when you have finished the simulations you are free to go.
Next week: Ion gradients!
Why?
Because V = IR

17. Concept Map Resistance Capacitance Cell Membrane Ion channels
Time constant
Current
Conductance
Voltage
Temporal Fidelity
Temporal Summation