1. Effects of Methylprednisolone and a Biocompatible Copolymer Circuit on Blood Activation During Cardiopulmonary Bypass 
Fraser D. Rubens, MD, Howard Nathan, MD, Rosalind Labow, PhD, Kathryn S. Williams, MS, Denise Wozny, BA, Jacob Karsh, MD, Marc Ruel, MD, Thierry Mesana, MD, PhD 
The Annals of Thoracic Surgery 
Volume 79, Issue 2, Pages (February 2005)
DOI: /j.athoracsur
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Elastase release related to cardiopulmonary bypass (CPB) in the four study groups. Repeated measures: SMA effect, p = 0.026; MPSS effect, p = 0.849; SMA*MPSS interactive effect, p = 0.681; time effect, p < 0.001; SMA effect over time, p = 0.251; MPSS effect over time, p = 0.437; SMA*MPSS interactive effect over time, p = Sampling times as indicated in the methods. Levels are mean values ± standard error of the mean at each time point (n = 17). –○– = SMA-CPB;  · · • · · = MPSS; –•– = SMA-CPB and MPSS;  · · ○ · · = neither. (MPSS = methylprednisolone; post-hep = postheparin; pre-hep = preheparin; PP = postprotamine; SMA = surface modifying additive; XC off = cross-clamp off.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Cytokine release during and after cardiopulmonary bypass (CPB). (A) IL-6 release related to CPB in the four study groups. Repeated measures: SMA effect, p = 0.180; MPSS effect, p = 0.007; SMA*MPSS interactive effect, p = 0.390; time effect, p < 0.001; SMA effect over time, p = 0.733; MPSS effect over time, p < 0.001; SMA*MPSS interactive effect over time, p = (B) IL-8 release related to CPB in the four study groups. Repeated measures: SMA effect, p = 0.730; MPSS effect, p < 0.001; SMA*MPSS interactive effect, p = 0.383; time effect, p = Sampling times as indicated in the methods. Levels are mean values ± standard error of the mean at each time point (n = 17). –○– = SMA-CPB; · · • · · = MPSS; –•– = SMA-CPB and MPSS; · · ○ · · = neither. (IL = interleukin; MPSS = methylprednisolone; post-hep = postheparin; pre-hep = preheparin; PP = postprotamine; SMA = surface modifying additive; XC off = cross-clamp off.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

4. Fig 3
Terminal complement complex (TCC) levels related to cardiopulmonary bypass (CPB) in the four study groups. The release of TCC was inhibited as an effect of SMA at the time of aortic cross-clamp release (t test, p = 0.047). Repeated measures: SMA effect, p = 0.042; MPSS effect, p = 0.650; SMA*MPSS interactive effect, p = 0.042; time effect, p < 0.001; SMA effect over time, p = 0.100; MPSS effect over time, p < 0.850; SMA*MPSS interactive effect over time, p = Levels are mean values ± standard error of the mean at each time point (n = 17). –○– = SMA-CPB;  · · • · · = MPSS; –•– = SMA-CPB and MPSS;  · · ○ · · = neither. (MPSS = methylprednisolone; post-hep = postheparin; pre-hep = preheparin; PP = postprotamine; SMA = surface modifying additive; XC off = cross-clamp off.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

5. Fig 4
Tissue plasminogen activator (tPA) antigen levels related to cardiopulmonary bypass (CPB) in the four study groups. Levels are mean values ± standard error of the mean in the four groups (n = 17). Repeated measures; SMA effect, p = 0.787; MPSS effect, p = 0.294; SMA*MPSS interactive effect, p = 0.263; time effect, p < 0.001; SMA effect over time, p = 0.797; MPSS effect over time, p = 0.009; SMA*MPSS interactive effect over time, p = Sampling times as indicated in the methods. –○– = SMA-CPB; · · • · · = MPSS; –•– = SMA-CPB and MPSS; · · ○ · · = neither. (MPSS = methylprednisolone; post-hep = postheparin; pre-hep = preheparin; SMA = surface modifying additive.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions