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The prevalence and natural course of food protein–induced enterocolitis syndrome to cow’s milk: A large-scale, prospective population-based study  Yitzhak.

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Presentation on theme: "The prevalence and natural course of food protein–induced enterocolitis syndrome to cow’s milk: A large-scale, prospective population-based study  Yitzhak."— Presentation transcript:

1 The prevalence and natural course of food protein–induced enterocolitis syndrome to cow’s milk: A large-scale, prospective population-based study  Yitzhak Katz, MD, Michael R. Goldberg, MD, PhD, Nelly Rajuan, MSc, Adi Cohen, MD, Moshe Leshno, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 3, Pages e3 (March 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Cohort description. Any patient in whom an adverse reaction to CMP was suspected (n = 381) was interviewed by one of the investigators (N. R.) and invited for an examination. A total of 44 patients with FPIES were given diagnoses, including 8 patients who converted to cases of secondary IgE-CMA. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Age distribution for the onset of FPIES. All patients had FPIES before the age of 180 days. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Dose of milk eliciting a response during oral challenge.
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Response time from last dose to clinical symptoms during OFC.
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Kaplan-Meier plot for the cumulative probability of recovery from CMP-induced FPIES. More than 90% of patients recovered from FPIES after 900 days. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Clinical characteristic of patients with FPIES
Clinical characteristic of patients with FPIES. The number of patients exhibiting each clinical symptom is depicted within the bar. The data are based on historical information from the parents or when available from the OFC. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Days of consumption of CMP before the development of symptoms.
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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