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Fig. 2 Adult LPL−/− mice that received neonatal rGM-CSF therapy are protected from pneumococcal infection. Adult LPL−/− mice that received neonatal rGM-CSF.

Published byBruce Dalton Modified over 5 years ago

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Presentation on theme: "Fig. 2 Adult LPL−/− mice that received neonatal rGM-CSF therapy are protected from pneumococcal infection. Adult LPL−/− mice that received neonatal rGM-CSF."— Presentation transcript:

1 Fig. 2 Adult LPL−/− mice that received neonatal rGM-CSF therapy are protected from pneumococcal infection. Adult LPL−/− mice that received neonatal rGM-CSF therapy are protected from pneumococcal infection. (A) Experimental design: Neonatal WT and LPL−/− pups were intranasally given 20 ng of rGM-CSF or PBS (control) on DOB, PND1, and PND2. After reaching adulthood, mice were challenged intratracheally (i.t.) with pneumococcus. (B) Adult WT (gray) or LPL−/− (black) mice that had received neonatal rGM-CSF therapy (open symbols) or PBS (control; closed symbols) were infected intratracheally with pneumococcus and monitored for survival. Survival curves show data combined from three independent experiments (WT + PBS, n = 19; WT + rGM-CSF, n = 7; LPL−/− + PBS, n = 11; LPL−/− + rGM-CSF, n = 16) and were compared using Mantel-Cox log-rank test. (C) Quantitative blood culture obtained from adult mice 24 hours after intratracheal instillation of pneumococci. Comparison of all groups by one-way analysis of variance (ANOVA) (Kruskal-Wallis test), P = (D) Distribution of neutrophils [polymorphonuclear leukocytes (PMNs)], monocytes, and B cells in the peripheral blood of WT and LPL−/− mice challenged with pneumococcus. Mice had received neonatal rGM-CSF therapy (GM) or PBS (P; control). (E) Number of AMs recovered from BAL fluid of WT or LPL−/− adult mice that survived 2 weeks after intratracheal pneumococcal infection. Grossly bloody BAL fluids were excluded from analysis (clotted). (F) Distribution of DCs, eosinophils, neutrophils (PMNs), and monocytes in whole-lung homogenates from uninfected adult WT and LPL−/− mice that had received neonatal rGM-CSF therapy or PBS (control). Percentages of total CD45+ cells are given. (C to F) Data are combined from three (C to E) or two (F) independent experiments. n of each group is given below x axes. P values of comparisons between two groups are determined using the Mann-Whitney U test. Elizabeth M. Todd et al. Sci Adv 2019;5:eaax3387 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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