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Genetic Anthropology of the Colorectal Cancer–Susceptibility Allele APC I1307K: Evidence of Genetic Drift within the Ashkenazim  Bethany L. Niell, Jeffrey.

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Presentation on theme: "Genetic Anthropology of the Colorectal Cancer–Susceptibility Allele APC I1307K: Evidence of Genetic Drift within the Ashkenazim  Bethany L. Niell, Jeffrey."— Presentation transcript:

1 Genetic Anthropology of the Colorectal Cancer–Susceptibility Allele APC I1307K: Evidence of Genetic Drift within the Ashkenazim  Bethany L. Niell, Jeffrey C. Long, Gad Rennert, Stephen B. Gruber  The American Journal of Human Genetics  Volume 73, Issue 6, Pages (December 2003) DOI: /379926 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Representative genotypes of APC I1307K carriers. A, Conserved allele at D5S346 among I1307K carriers observed among Ashkenazi Jews (lanes 1–3), Sephardi Jews (lanes 4–6), and Arabs (lanes 7–9) (arrow). B, Absence of conserved genotype at D5S82 among Ashkenazi Jews (lanes 1–3), Sephardi Jews (lanes 4–6), or Arabs (lanes 7–9). The American Journal of Human Genetics  , DOI: ( /379926) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Conserved alleles at markers linked to I1307K. These alleles, shown for homozygous positive individuals, construct a putative progenitor haplotype of the most recent common ancestor of I1307K. The American Journal of Human Genetics  , DOI: ( /379926) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

4 Figure 3 Timeline of selected events in the history of the Jewish peoples The American Journal of Human Genetics  , DOI: ( /379926) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

5 Figure 4 The Jewish diasporas. The existence of APC I1307K prior to the Jewish diasporas explains its presence in non-Ashkenazi peoples residing in geographic locales populated by the diasporas. Adapted from Barnavi (1992). The American Journal of Human Genetics  , DOI: ( /379926) Copyright © 2003 The American Society of Human Genetics Terms and Conditions


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