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Nomenclature of Voltage-Gated Calcium Channels

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1 Nomenclature of Voltage-Gated Calcium Channels
Eric A. Ertel, Kevin P. Campbell, Michael M. Harpold, Franz Hofmann, Yasuo Mori, Edward Perez-Reyes, Arnold Schwartz, Terry P. Snutch, Tsutomu Tanabe, Lutz Birnbaumer, Richard W. Tsien, William A. Catterall  Neuron  Volume 25, Issue 3, Pages (March 2000) DOI: /S (00)

2 Figure 1 Phylogeny of Voltage-Gated Ca2+ Channel α1 Subunits
Only the membrane-spanning segments and the pore loops (∼350 amino acids) are compared. First, all sequence pairs were compared, which clearly defines three families with intrafamily sequence identities above 80% (CaV1.m, CaV2.m, CaV3.m). Then, a consensus sequence was defined for each family, and these three sequences were compared to one another, with interfamily sequence identities of ∼52% (CaV1.m versus CaV2.m) and 28% (CaV3.m versus CaV1.m or CaV2.m). Neuron  , DOI: ( /S (00) )


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