1. Fig. 3 Imaging-guided S-HDL nanoimmunotherapy in rabbits and pigs: PET-based readouts.
Imaging-guided S-HDL nanoimmunotherapy in rabbits and pigs: PET-based readouts. (A) Schematic representation of S-HDL imaging–guided treatment. Treatment response was evaluated longitudinally by performing a baseline scan before the first S-HDL administration and a terminal scan 48 hours after the last infusion. Animals received four infusions over 2 weeks. (B)18F-FDG-PET imaging–based assessment of vessel wall inflammation in rabbits (n = 5 per group; top) and pigs (n = 4 per group; bottom) treated with PBS (placebo) or S-HDL. Scale bars, 10 mm. (C) 18F-FLT-PET imaging–based assessment of cellular proliferation in the vessel wall in rabbits (n = 4 per group; top) and pigs (n = 4 per group; bottom) treated with PBS (placebo) or S-HDL. Scale bars, 10 mm. In (B) and (C), dots are color-coded for individual animals, and two data points are represented per pig, corresponding to values obtained from analysis of each of the femoral arteries. Line is situated at median. TBRmax, maximal target-to-background ratio. Data were obtained in one experiment and analyzed using a linear mixed model (see the “Statistical analysis” section for details).
Tina Binderup et al., Sci Transl Med 2019;11:eaaw7736
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works