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Hitting HIV’s Harpoon Immunity
Marit J. van Gils, Rogier W. Sanders Immunity Volume 49, Issue 1, Pages (July 2018) DOI: /j.immuni Copyright © 2018 Elsevier Inc. Terms and Conditions
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Figure 1 Focusing on the Fusion Peptide of the HIV-1 Envelope Glycoprotein Top: Homing in on the FP of HIV-1 and the role of the FP in the fusion of viral and cellular membranes. Bottom: Immunization of mice resulted in antibodies that neutralized heterologous virus strains but with lower potency and breadth compared to human bNAbs. Immunization of NHPs resulted in serum activity that neutralized up to 20% of heterologous strains. Abbreviations: FP, fusion peptide; MAb, monoclonal antibody; IC50, 50% inhibitory concentration; ID50, 50% inhibitory reciprocal serum dilution. Immunity , 14-15DOI: ( /j.immuni ) Copyright © 2018 Elsevier Inc. Terms and Conditions
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