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Fig. 1 Structure of the α-SNAP–SNARE subcomplex.

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Presentation on theme: "Fig. 1 Structure of the α-SNAP–SNARE subcomplex."— Presentation transcript:

1 Fig. 1 Structure of the α-SNAP–SNARE subcomplex.
Structure of the α-SNAP–SNARE subcomplex. (A) The EM density map of the α-SNAP–SNARE subcomplex color-coded to show the local resolution as estimated by ResMap. The right panel shows a cut-through view of the interior of the map. (B) Cryo-EM density (mesh) of representative layers of the SNARE complex superimposed with respective atomic models (stick). Unsharpened map showing the extended density corresponding to the longer C terminus of VAMP is displayed in the inset. The red arrows indicate the extended density. (C) Interactions of each α-SNAP with the SNARE complex showing interacting residues. Eye symbols and arrowheads in the insets indicate view directions. Note that each α-SNAP molecule interacts with three of the four chains of the SNARE complex, and in each of the four α-SNAP molecules, almost an identical set of residues make contact with SNARE, but on the receiving side, different sets of residues are used by individual SNARE chains. Xuan Huang et al. Sci Adv 2019;5:eaau8164 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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