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Volume 23, Issue 16, Pages (August 2013)

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1 Volume 23, Issue 16, Pages 1596-1600 (August 2013)
Identification of Regions Associated with Variation in Sensitivity to Food-Related Odors in the Human Genome  Jeremy F. McRae, Sara R. Jaeger, Christina M. Bava, Michelle K. Beresford, Denise Hunter, Yilin Jia, Sok Leang Chheang, David Jin, Mei Peng, Joanna C. Gamble, Kelly R. Atkinson, Lauren G. Axten, Amy G. Paisley, Liam Williams, Leah Tooman, Benedicte Pineau, Simon A. Rouse, Richard D. Newcomb  Current Biology  Volume 23, Issue 16, Pages (August 2013) DOI: /j.cub Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Figure 1 Distributions of Detection Threshold Concentrations for Odors Tested in This Study (A) 1,8-cineole, (B) 2-heptanone, (C) hircinoic acid, (D) cis-3-hexen-1-ol, (E) dipropyl disulfide, (F) isobutyraldehyde, (G) isovaleric acid, (H) vanillin, (I) β-damascenone, and (J) β-ionone. Chemical structures of each odor compound are provided at the top of each distribution plot. See also Figure S1. Current Biology  , DOI: ( /j.cub ) Copyright © 2013 Elsevier Ltd Terms and Conditions

3 Figure 2 Manhattan Plots for the Four Odors with Significant Genetic Associations (A) 2-heptanone, (B) isobutyraldehyde, (C) β-damascenone, and (D) β-ionone. Alternate chromosomes are shown in alternating colors. Arrows indicate the locations of the best associated regions for each odor. See also Figure S2. Current Biology  , DOI: ( /j.cub ) Copyright © 2013 Elsevier Ltd Terms and Conditions

4 Figure 3 Regional Association Plots Showing Regions of Association Colocating with Clusters of Olfactory Receptor Genes For each of (A) 2-heptanone, (B) isobutyraldehyde, (C) β-damascenone, and (D) β-ionone regional variants are plotted according to their –log10 p value and chromosome position (GRCh37). Variants genotyped using SNP 6.0 arrays are shaded blue, and imputed variants are shaded gray. Estimated recombination rates from HapMap populations are plotted to show local linkage disequilibrium. The locations of genes within each associated region are shown beneath each association plot, with olfactory receptor (OR) genes shaded red. Non-OR gene annotations were obtained from the UCSC Genome browser, and OR gene annotations were obtained from the Human Olfactory Data Explorer database. Distributions of detection threshold concentrations by genotype for the strongest associated variants for each of the four odors are shown to the right of the regional association plots. See also Figure S3, Table S1, and Table S2. Current Biology  , DOI: ( /j.cub ) Copyright © 2013 Elsevier Ltd Terms and Conditions

5 Figure 4 Frequencies of Sensitivity Groups for 2-Heptanone, Isobutyraldehyde, β-Damascenone, and β-Ionone among 1000 Genomes Populations Sensitivity frequencies are predicted according to the frequency of the less sensitive genotype/s for each of rs , rs , rs , and rs , placed on the map according to the ancestral recruitment areas. See also Figure S4 and Tables S3–S6. Current Biology  , DOI: ( /j.cub ) Copyright © 2013 Elsevier Ltd Terms and Conditions


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