1. Experimental metastasis inhibition by primary tumors is mediated by NK cells and IFNγ.
Experimental metastasis inhibition by primary tumors is mediated by NK cells and IFNγ. A, Total cell numbers of NK cells and NK cell activation status in the lungs on days 0, 1, 2, and 3 after metastasis induction in primary tumor-free (open symbols) or tumor-bearing (closed symbols) mice (n = 4 for each group). Data are representative of two independent experiments. B, Number of B16F10 lung metastatic nodules in primary tumor-free or primary tumor-bearing mice (as in Fig. 1B) upon NK cell depletion using anti-NK1.1 mAb (n = 4 for each group. C, B16F10 lung metastatic nodules in IFNγ−/− mice in the presence or absence of primary tumor (n = 3–4 for each group). Each symbol represents one animal. *, P < 0.05; **, P < 0.01; ***, P < (unpaired two-tailed t test).
Hiroshi Kubo et al. Cancer Immunol Res 2017;5:
©2017 by American Association for Cancer Research