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Emmet B. Keeffe, Douglas T

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1 Chronic Hepatitis B: Preventing, Detecting, and Managing Viral Resistance 
Emmet B. Keeffe, Douglas T. Dieterich, Jean–Michel Pawlotsky, Yves Benhamou  Clinical Gastroenterology and Hepatology  Volume 6, Issue 3, Pages (March 2008) DOI: /j.cgh Copyright © 2008 AGA Institute Terms and Conditions

2 Figure 1 Location of the major antiviral drug-resistant mutations associated with LMV, LdT, ADV, TDF, and ETV11 (Reprinted with permission). LMV, lamivudine; Ldt, telbuvidine; ADV, adefovir dipivoxil; TDF, tenofovir DF; ETV, entecavir. POL/RT, polymerase reverse-transcriptase. Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions

3 Figure 2 Serial changes in serum HBV DNA and ALT levels in association with emergence of antiviral-resistant HBV mutants. The first manifestation of resistance is the detection of resistance-conferring mutations (ie, genotypic resistance).46 (Reprinted with permission). ULN, upper limit of normal. Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions


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