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Fig. 5 IL-4Rα−/− offspring nursed on NbM dams have enhanced lymphocyte-mediated immunity against Nb infection. IL-4Rα−/− offspring nursed on NbM dams have.

Published byJakob Berglund Modified over 5 years ago

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Presentation on theme: "Fig. 5 IL-4Rα−/− offspring nursed on NbM dams have enhanced lymphocyte-mediated immunity against Nb infection. IL-4Rα−/− offspring nursed on NbM dams have."— Presentation transcript:

1 Fig. 5 IL-4Rα−/− offspring nursed on NbM dams have enhanced lymphocyte-mediated immunity against Nb infection. IL-4Rα−/− offspring nursed on NbM dams have enhanced lymphocyte-mediated immunity against Nb infection. (A) Three-day-old IL-4Rα−/− pups were fostered on either WT NvM or NbM dams. Offspring were infected when 14 days old with 250 × Nb L3 and euthanized at day 5 PI, and intestinal worm burdens were quantified. (B) Nb-specific serum IgG1, anti-CD3 restimulated splenocyte IL-13, lung homogenate levels of IL-13, and CD3+CD4+IL-13+ T cells/MST were quantified in IL-4Rα−/− pups. (C) Numbers of immune cells in breast milk pellets from the stomachs of 10-day-old pups nursed by WT NvM or NbM dams. All data are representative of a minimum of two experimental repeats. *P < 0.05, **P < 0.01, and ***P < Matthew G. Darby et al. Sci Adv 2019;5:eaav3058 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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