1. HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia 
Mandy Johnstone, Rana Fetit 
Cell Stem Cell 
Volume 22, Issue 5, Pages (May 2018)
DOI: /j.stem
Copyright © 2018 Elsevier Inc. Terms and Conditions

2. Figure 1
Schematic Overview of the Experimental Design Adopted in the Sarkar et al. Study
The 2D cyto-architecture of the hippocampus was recapitulated in vitro by the generation and characterization of a panel of human iPSC and hESC-derived hippocampal cells (CA3s and DGs). Labeling the CA3 neurons (using lentiviral GRIK4-eGFP or Elval2-reporter constructs), which permitted immunocytochemistry of the DG-CA3 co-cultures as well as Rabies virus trans-neuronal tracing, demonstrated connectivity. Collectively, the studies demonstrated important structural and functional differences in synaptic connectivity between schizophrenia patient-derived cells and unaffected controls.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2018 Elsevier Inc. Terms and Conditions