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R. D. Gray, M. Imrie, A. C. Boyd, D. Porteous, J. A. Innes, A. P

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Presentation on theme: "R. D. Gray, M. Imrie, A. C. Boyd, D. Porteous, J. A. Innes, A. P"— Presentation transcript:

1 Sputum and serum calprotectin are useful biomarkers during CF exacerbation 
R.D. Gray, M. Imrie, A.C. Boyd, D. Porteous, J.A. Innes, A.P. Greening  Journal of Cystic Fibrosis  Volume 9, Issue 3, Pages (May 2010) DOI: /j.jcf Copyright © 2010 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Panel A. Sputum calprotectin decreases over the course of an exacerbation following treatment with antibiotics; p= Individual data are shown for 27 subjects. Panel B. Serum calprotectin decreases over the course of an exacerbation following treatment with antibiotics; p= Individual data are shown for 25 subjects. Journal of Cystic Fibrosis 2010 9, DOI: ( /j.jcf ) Copyright © 2010 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 Serum VEGF decreases over the course of an exacerbation following treatment with antibiotics; p= Individual data are shown for 23 subjects. Journal of Cystic Fibrosis 2010 9, DOI: ( /j.jcf ) Copyright © 2010 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 Panel A. Subjects with serum calprotectin of 9.1mg/ml at the end of exacerbation treatment have longer time to next exacerbation with median time to exacerbation 112days vs. 70days (p=0.032). Panel B. Serum CRP of <10mg/ml did not differentiate time to next exacerbation with median time to exacerbation of 81 vs. 83.5days (p=0.125). Journal of Cystic Fibrosis 2010 9, DOI: ( /j.jcf ) Copyright © 2010 European Cystic Fibrosis Society. Terms and Conditions


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