1. Cross talk between the virulence elements.
Cross talk between the virulence elements. The reported effects of SirA and CsrA on flagellar genes are not considered in this scheme, since no direct evidence of independent HilA activity have been presented. The regulatory effects that flagellar genes exert on SPI-1 and type I fimbriae are mediated by FliZ, whereas SPI-1 repression of flagellar genes is dependent on HilA activity. The influence of biofilm on SPI-1 expression is mediated by CsgD.
Anna Fàbrega, and Jordi Vila Clin. Microbiol. Rev. 2013; doi: /CMR