Presentation is loading. Please wait.

Presentation is loading. Please wait.

Single-cell analyses to tailor treatments

Published byCharles Singleton Modified over 5 years ago

Similar presentations

Presentation on theme: "Single-cell analyses to tailor treatments"— Presentation transcript:

1 Single-cell analyses to tailor treatments
by Alex K. Shalek, and Mikael Benson Sci Transl Med Volume 9(408):eaan4730 September 20, 2017 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

2 Fig. 1. scRNA-seq applications in cancer medicine.
scRNA-seq applications in cancer medicine. (A) Bulk analysis of a tumor identifies the predominant malignant clone and suggests a drug to target it but not other clones. (B) scRNA-seq resolves each clone within a tumor, as well as the corresponding biomarkers and cognate drugs, enabling successful therapy. (C) Longitudinal profiling of patient samples with scRNA-seq (or biomarkers discovered with it) can be used to monitor disease state and select the appropriate time to treat, given the benefits and costs of intervention. (D) Analysis of samples before and after treatment may reveal subsets refractory to a given therapy, as well as their biomarkers and mechanisms of resistance. (E) Because of its sensitivity, scRNA-seq might also be used in a clinical setting for detection of rare disease-associated cells (such as minimal residual disease), which would have been missed by bulk analyses. Alex K. Shalek and Mikael Benson Sci Transl Med 2017;9:eaan4730 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

Download ppt "Single-cell analyses to tailor treatments"

Similar presentations

CsEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.

CsEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.
Fig. 1. scRNA-seq applications in cancer medicine.

Fig. 1. scRNA-seq applications in cancer medicine.
Fig. 5 Correlation of RNA expression and protein abundance.

Fig. 5 Correlation of RNA expression and protein abundance.
Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,
Fig. 4 Mutations and reduced expression of human KDM6A predict poor prognosis of female patients with BCa. Mutations and reduced expression of human KDM6A.

Fig. 4 Mutations and reduced expression of human KDM6A predict poor prognosis of female patients with BCa. Mutations and reduced expression of human KDM6A.
Fig. 3 Vibrational spectra of human bones from the Copper Age (Scoglietto cave, Italy). Vibrational spectra of human bones from the Copper Age (Scoglietto.

Fig. 3 Vibrational spectra of human bones from the Copper Age (Scoglietto cave, Italy). Vibrational spectra of human bones from the Copper Age (Scoglietto.
Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)
Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.

Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.
Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.
Fig. 1 Map of water stress and shale plays.

Fig. 1 Map of water stress and shale plays.
In vivo release of doxycycline hyclate from the GRS in a swine model

In vivo release of doxycycline hyclate from the GRS in a swine model
Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 1 Examples of experimental stimuli and behavioral performance.
Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.
Fig. 6 Comparison of properties of water models.

Fig. 6 Comparison of properties of water models.
Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.
Fig. 2 Reference-fixing experiment, results.

Fig. 2 Reference-fixing experiment, results.
Fig. 2 Ferroelectric domains resolved in WTe2 single crystals.

Fig. 2 Ferroelectric domains resolved in WTe2 single crystals.
Fig. 3 Glucose- and structure-dependent insulin release.

Fig. 3 Glucose- and structure-dependent insulin release.
Fig. 3 Scan rate effects on the layer edge current.

Fig. 3 Scan rate effects on the layer edge current.
Fig. 2 TRXSS data. TRXSS data. TRXSS data covering delay times from 10 ns to 10 ms for wild-type DmCry (A), for the DmCry(H378A) mutant (B), and for XlPho.

Fig. 2 TRXSS data. TRXSS data. TRXSS data covering delay times from 10 ns to 10 ms for wild-type DmCry (A), for the DmCry(H378A) mutant (B), and for XlPho.

Similar presentations

Ads by Google