1. Stages of biofilm development (214).
Stages of biofilm development (214). The first stage of biofilm formation in bone is attachment. Once attached, the bacteria begin to accumulate and produce a sticky matrix, which is the initial biofilm. This accumulation results in the formation of biofilm microcolonies and development of mature biofilm. The biofilm may then finally break down and release the bacteria from within, causing dissemination throughout the host.
Nicola Kavanagh et al. Clin. Microbiol. Rev. 2018; doi: /CMR